In the world of non-surgical cosmetic treatments, neuromodulators have revolutionized how we reduce fine lines, smooth wrinkles, and maintain a youthful appearance—all without going under the knife. From household names like Botox to innovative newcomers like Daxxify, patients today have more options than ever.

But how do you know which neuromodulator is right for you?

In this guide, we break down the five most popular FDA-approved neuromodulators—Botox vs Jeuveau vs Dysport vs Xeomin vs Daxxify—to help you understand their differences in composition, duration, cost, and ideal usage so you can make an informed decision.

What Are Neuromodulators?

Neuromodulators are neurotoxin injectable treatments that temporarily block nerve signals to facial muscles. This prevents muscle contractions that cause expression lines, leading to a smoother, more refreshed look. Common treatment areas include the forehead, crow’s feet, glabellar lines (frown lines), and more.

Neuromodulator Comparison Table

Note: Costs vary depending on provider, area treated, and geographic location. Always consult your med spa or dermatologist for exact pricing.

Comparison between Botox vs Jeuveau vs Dysport vs Xeomin vs Daxxify

Botox

Overview: Botox, made by Allergan, is the pioneer in neuromodulators and has been the go-to wrinkle treatment since its FDA approval for cosmetic use in 2002.

Composition: OnabotulinumtoxinA—purified botulinum toxin type A.

Onset & Duration: Effects begin in 3 to 5 days, with full results within 7–14 days. Lasts about 3 to 4 months.

Best For:

• Fine lines on forehead
• Crow’s feet
• Frown lines between eyebrows

Why Choose Botox?

• Most widely studied
• Proven safety record
• Trusted by millions

Jeuveau

Overview: Nicknamed “Newtox,” Jeuveau by Evolus entered the market in 2019 with a modern, millennial-focused brand approach. It’s FDA-approved for glabellar lines.

Composition: PrabotulinumtoxinA—similar to Botox in structure and function.

Onset & Duration: Effects begin similarly to Botox: Results appear in 3 to 5 days, lasting 3 to 4 months.

Best For:

• First-time users
• Younger adults aiming for preventive care
• Frown lines

Why Choose Jeuveau?

• Often priced more affordably than Botox
• Marketed with a lifestyle-forward image

Dysport

Overview: Approved in the U.S. in 2009, Dysport by Ipsen is known for its fast onset and wider spread, making it ideal for treating larger areas.

Composition: AbobotulinumtoxinA—another form of botulinum toxin A, with a different molecular structure that allows faster diffusion.

Onset & Duration: Takes effect in 2 to 3 days, slightly faster than Botox. Results last around 3 to 4 months.

Best For:

• Broad forehead treatment
• Patients who want fast results

Why Choose Dysport?

• Faster onset
• May require more units, but less cost per unit
• Smooth, natural-looking results

Xeomin

Overview: FDA-approved in 2010, Xeomin by Merz Pharmaceuticals is called the “naked injectable” because it’s free from accessory proteins.

Composition: IncobotulinumtoxinA—purified botulinum toxin A without complexing proteins, reducing risk of immune resistance.

Onset & Duration: Begins working in 3 to 4 days, lasting around 3 to 4 months.

Best For:

• Patients who’ve developed resistance to Botox or Dysport
• Sensitive skin

Why Choose Xeomin?

• Purified formulation
• Less risk of antibody resistance
• FDA-approved for frown lines and off-label areas

Daxxify

Overview: Daxxify, the newest on the block, was FDA-approved in 2022. It’s formulated with a unique peptide-stabilized botulinum toxin that makes it last significantly longer than its counterparts.

Composition: DaxibotulinumtoxinA-lanm with a proprietary peptide that helps the product bind longer to nerve endings.

Onset & Duration: Results may appear as early as 1 to 2 days, with effects lasting 6 months or more.

Best For:

• Busy professionals
• Long-term results seekers
• Moderate to severe frown lines

Why Choose Daxxify?

• Longest duration on the market
• Fewer injection appointments per year
• Ongoing studies for other cosmetic and therapeutic uses

How Much Do Neuromodulators Cost in the USA?

Neuromodulator prices vary depending on:

• Number of units needed
• Area being treated
• Geographic location
• Provider’s expertise

Here’s a quick U.S.-based cost overview:

Note: Always schedule a consultation to get a personalized quote based on your facial structure, goals, and dosage needs.

Conclusion: Which Neuromodulator Is Right for You?

While all five neuromodulators serve the same core function—relaxing muscles to smooth lines and wrinkles—they are not one-size-fits-all. Your age, goals, lifestyle, and prior experiences will influence your ideal choice.

Quick Tips:

• Go with Botox if you want the gold-standard, widely trusted treatment.
• Try Jeuveau if you’re younger or budget-conscious.
• Opt for Dysport for quicker results or larger treatment areas.
• Choose Xeomin if you’ve built up a resistance to other products.
• Select Daxxify if you want the longest-lasting results with fewer visits.

Ready to refresh your look? Schedule a consultation at Serenity Med Spa of Georgia to get personalized recommendations and discover which neuromodulator is perfect for your skin.

FAQs: Neuromodulators Explained

Q: What is Botox?
A: Botox is an FDA-approved neuromodulator made from onabotulinumtoxinA. It temporarily relaxes facial muscles to reduce wrinkles and fine lines.

Q: What is Jeuveau?
A: Jeuveau is a botulinum toxin injectable (prabotulinumtoxinA) used for cosmetic wrinkle reduction, primarily frown lines. It’s often called “Newtox.”

Q: Which lasts longer—Botox or Jeuveau?
A: Both last about 3 to 4 months, though some users report slight differences. Jeuveau may work faster for some, but duration is comparable.

Q: What is Dysport used for?
A: Dysport treats moderate to severe frown lines, forehead lines, and can be used off-label for other wrinkles. Its spread makes it great for large areas.

Q: Is Dysport better than Botox?
A: Not necessarily better—just different. Dysport has a quicker onset and wider spread. Botox is more concentrated and precise.

Q: What is Xeomin best for?
A: Xeomin is ideal for patients who want a pure formulation or may have developed resistance to other neuromodulators.

Q: What is Daxxify?
A: Daxxify is a long-lasting neuromodulator that lasts up to 6 months or more, thanks to a peptide-stabilized botulinum toxin formula.

Q: How long does Daxxify last?
A: Most users see results for 6 months, and some enjoy effects for up to 9 months. It’s currently the longest-lasting neuromodulator available.

Q: Where can I get Botox or Daxxify in Georgia?
A: Visit Serenity Med Spa of Georgia for expert neuromodulator treatments tailored to your needs. Schedule your consultation today!

Q: Are neuromodulators the same as dermal fillers?
A: No. Neuromodulators like Botox and Daxxify relax facial muscles to reduce dynamic wrinkles (those caused by expressions). Dermal fillers, on the other hand, restore lost volume and enhance facial contours. They’re often used together for full-face rejuvenation.